Arizona Cardinals vs San Francisco 49ers:All-Time Matchup History

Matchup Overview

The Arizona Cardinals and San Francisco 49ers have met 69 times in NFL regular-season and playoff games since 1951. San Francisco 49ers hold a clear edge in the all-time series, 38–31. San Francisco 49ers have had the upper hand recently, going 3–2 in their last 5 meetings. Their most recent matchup ended 36–30 in favor of San Francisco 49ers on September 27, 2026. They are scheduled to meet again on January 9, 2027 at State Farm Stadium, Glendale.

Next Meeting

San Francisco 49ersAway

@Sat, Jan 97:00 PM ESTWeek 18State Farm Stadium, Glendale

Arizona CardinalsHome

All-Time Head-to-Head

Showing 69 games from available historical data. Preseason games are not included.

Date	Season	Away	Score	Home
Sep 27, 26	2026 W3	ARI	30–36	SF
Nov 16, 25	2025 W11	SF	41–22	ARI
Sep 21, 25	2025 W3	ARI	15–16	SF
Jan 5, 25	2024 W18	SF	24–47	ARI
Oct 6, 24	2024 W5	ARI	24–23	SF
Dec 17, 23	2023 W15	SF	45–29	ARI
Oct 1, 23	2023 W4	ARI	16–35	SF
Jan 8, 23	2022 W18	ARI	13–38	SF
Nov 21, 22	2022 W11	SF	38–10	ARI
Nov 7, 21	2021 W9	ARI	31–17	SF
Oct 10, 21	2021 W5	SF	10–17	ARI
Dec 26, 20	2020	SF	20–12	ARI
Sep 13, 20	2020	ARI	24–20	SF
Nov 17, 19	2019	ARI	26–36	SF
Oct 31, 19	2019	SF	28–25	ARI
Oct 28, 18	2018	SF	15–18	ARI
Oct 7, 18	2018	ARI	28–18	SF
Nov 5, 17	2017	ARI	20–10	SF
Oct 1, 17	2017	SF	15–18	ARI
Nov 13, 16	2016	SF	20–23	ARI
Oct 6, 16	2016	ARI	33–21	SF
Nov 29, 15	2015	ARI	19–13	SF
Sep 27, 15	2015	SF	7–47	ARI
Dec 28, 14	2014	ARI	17–20	SF
Sep 21, 14	2014	SF	14–23	ARI
Dec 29, 13	2013	SF	23–20	ARI
Oct 13, 13	2013	ARI	20–32	SF
Dec 30, 12	2012	ARI	13–27	SF
Oct 29, 12	2012	SF	24–3	ARI
Dec 11, 11	2011	SF	19–21	ARI
Nov 20, 11	2011	ARI	7–23	SF
Nov 29, 10	2010	SF	27–6	ARI
Dec 13, 09	2009	ARI	9–24	SF
Sep 12, 09	2009	SF	20–16	ARI
Nov 9, 08	2008	SF	24–29	ARI
Sep 6, 08	2008	ARI	23–13	SF
Nov 24, 07	2007	SF	37–31	ARI
Sep 9, 07	2007	ARI	17–20	SF
Dec 23, 06	2006	ARI	26–20	SF
Sep 9, 06	2006	SF	27–34	ARI
Dec 3, 05	2005	ARI	17–10	SF
Oct 1, 05	2005	ARI	31–14	SF
Dec 11, 04	2004	SF	31–28	ARI
Oct 9, 04	2004	ARI	28–31	SF
Dec 6, 03	2003	ARI	14–50	SF
Oct 25, 03	2003	SF	13–16	ARI
Dec 20, 02	2002	SF	17–14	ARI
Oct 26, 02	2002	ARI	28–38	SF
Sep 30, 00	2000	ARI	20–27	SF
Sep 26, 99	1999	SF	24–10	ARI
Oct 23, 93	1993	ARI	14–28	SF
Oct 31, 92	1992	SF	14–24	ARI
Nov 16, 91	1991	ARI	10–14	SF
Nov 5, 88	1988	SF	23–24	ARI
Oct 17, 87	1987	ARI	28–34	SF
Nov 8, 86	1986	ARI	17–43	SF
Sep 17, 83	1983	SF	42–27	ARI
Nov 20, 82	1982	SF	31–20	ARI
Sep 13, 80	1980	ARI	21–24	SF
Dec 1, 79	1979	SF	10–13	ARI
Nov 11, 78	1978	ARI	16–10	SF
Oct 30, 76	1976	SF	20–23	ARI
Oct 5, 74	1974	ARI	34–9	SF
Oct 23, 71	1971	SF	26–14	ARI
Sep 21, 68	1968	ARI	17–35	SF
Sep 26, 64	1964	ARI	23–13	SF
Nov 24, 62	1962	SF	24–17	ARI
Sep 28, 57	1957	ARI	20–10	SF
Nov 17, 51	1951	ARI	27–21	SF

Games before the 2010 season: Data from FiveThirtyEight, used under the MIT License and limited to today's franchises.