Matchup Overview

The Arizona Cardinals and San Francisco 49ers have met 32 times in NFL. San Francisco 49ers hold a clear edge in the all-time series, 17–15. San Francisco 49ers have had the upper hand recently, going 3–2 in their last 5 meetings. Their most recent matchup ended 41–22 in favor of San Francisco 49ers on November 16, 2025. They are scheduled to meet again on September 27, 2026 at Levi's Stadium, Santa Clara.

Next Meeting

Arizona CardinalsAway

@Sun, Sep 278:05 PM UTCWeek Week 3Levi's Stadium, Santa Clara

San Francisco 49ersHome

All-Time Head-to-Head

Showing 32 games from available historical data.

Date	Season	Away	Score	Home
Nov 16, 25	2025 WWeek 11	SF	41–22	ARI
Sep 21, 25	2025 WWeek 3	ARI	15–16	SF
Jan 5, 25	2024 WWeek 18	SF	24–47	ARI
Oct 6, 24	2024 WWeek 5	ARI	24–23	SF
Dec 17, 23	2023 WWeek 15	SF	45–29	ARI
Oct 1, 23	2023 WWeek 4	ARI	16–35	SF
Jan 8, 23	2022 WWeek 18	ARI	13–38	SF
Nov 22, 22	2022 WWeek 11	SF	38–10	ARI
Nov 7, 21	2021 WWeek 9	ARI	31–17	SF
Oct 10, 21	2021 WWeek 5	SF	10–17	ARI
Dec 26, 20	2020	SF	20–12	ARI
Sep 13, 20	2020	ARI	24–20	SF
Nov 17, 19	2019	ARI	26–36	SF
Oct 31, 19	2019	SF	28–25	ARI
Oct 28, 18	2018	SF	15–18	ARI
Oct 7, 18	2018	ARI	28–18	SF
Nov 5, 17	2017	ARI	20–10	SF
Oct 1, 17	2017	SF	15–18	ARI
Nov 13, 16	2016	SF	20–23	ARI
Oct 7, 16	2016	ARI	33–21	SF
Nov 29, 15	2015	ARI	19–13	SF
Sep 27, 15	2015	SF	7–47	ARI
Dec 28, 14	2014	ARI	17–20	SF
Sep 21, 14	2014	SF	14–23	ARI
Dec 29, 13	2013	SF	23–20	ARI
Oct 13, 13	2013	ARI	20–32	SF
Dec 30, 12	2012	ARI	13–27	SF
Oct 30, 12	2012	SF	24–3	ARI
Dec 11, 11	2011	SF	19–21	ARI
Nov 20, 11	2011	ARI	7–23	SF
Jan 2, 11	2010	ARI	7–38	SF
Nov 30, 10	2010	SF	27–6	ARI