NFL · All-Time Matchup
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Arizona Cardinals

VS
San Francisco 49ers logo

San Francisco 49ers

Arizona Cardinals vs San Francisco 49ers:All-Time Matchup History

Matchup Overview

The Arizona Cardinals and San Francisco 49ers have met 32 times in NFL. San Francisco 49ers hold a clear edge in the all-time series, 17–15. San Francisco 49ers have had the upper hand recently, going 3–2 in their last 5 meetings. Their most recent matchup ended 41–22 in favor of San Francisco 49ers on November 16, 2025.

Next Meeting

No upcoming game scheduled between these teams this season.

All-Time Head-to-Head

Showing 32 games from available historical data.

DateAwayScoreHome
Nov 16, 25
SF
41–22
ARI
Sep 21, 25
ARI
15–16
SF
Jan 5, 25
SF
24–47
ARI
Oct 6, 24
ARI
24–23
SF
Dec 17, 23
SF
45–29
ARI
Oct 1, 23
ARI
16–35
SF
Jan 8, 23
ARI
13–38
SF
Nov 22, 22
SF
38–10
ARI
Nov 7, 21
ARI
31–17
SF
Oct 10, 21
SF
10–17
ARI
Dec 26, 20
SF
20–12
ARI
Sep 13, 20
ARI
24–20
SF
Nov 17, 19
ARI
26–36
SF
Oct 31, 19
SF
28–25
ARI
Oct 28, 18
SF
15–18
ARI
Oct 7, 18
ARI
28–18
SF
Nov 5, 17
ARI
20–10
SF
Oct 1, 17
SF
15–18
ARI
Nov 13, 16
SF
20–23
ARI
Oct 7, 16
ARI
33–21
SF
Nov 29, 15
ARI
19–13
SF
Sep 27, 15
SF
7–47
ARI
Dec 28, 14
ARI
17–20
SF
Sep 21, 14
SF
14–23
ARI
Dec 29, 13
SF
23–20
ARI
Oct 13, 13
ARI
20–32
SF
Dec 30, 12
ARI
13–27
SF
Oct 30, 12
SF
24–3
ARI
Dec 11, 11
SF
19–21
ARI
Nov 20, 11
ARI
7–23
SF
Jan 2, 11
ARI
7–38
SF
Nov 30, 10
SF
27–6
ARI

Overall Record

since 2010

Arizona Cardinals
15
San Francisco 49ers
17
32 games in available data

Last 5 Meetings

SF41
@Nov 16
22ARI
ARI15
@Sep 21
16SF
SF24
@Jan 5
47ARI
ARI24
@Oct 6
23SF
SF45
@Dec 17
29ARI

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