NFL · All-Time Matchup
Buffalo Bills
VS
San Francisco 49ers
Buffalo Bills vs San Francisco 49ers:All-Time Matchup History
Matchup Overview
The Buffalo Bills and San Francisco 49ers have met 4 times in NFL. Buffalo Bills hold a dominant all-time edge, leading the series 3–1. Buffalo Bills have had the upper hand recently, going 3–1 in their last 4 meetings. Their most recent matchup ended 35–10 in favor of Buffalo Bills on December 2, 2024.
Next Meeting
No upcoming game scheduled between these teams this season.
All-Time Head-to-Head
Showing 4 games from available historical data.
| Date | Away | Score | Home |
|---|---|---|---|
| Dec 2, 24 | SF | 10–35 | BUF |
| Dec 8, 20 | BUF | 34–24 | SF |
| Oct 16, 16 | SF | 16–45 | BUF |
| Oct 7, 12 | BUF | 3–45 | SF |
Overall Record
since 2012
Buffalo Bills
3San Francisco 49ers
14 games in available data
Last 5 Meetings
SF10
@Dec 2
35BUF
BUF34
@Dec 8
24SF
SF16
@Oct 16
45BUF
BUF3
@Oct 7
45SF