Buffalo Bills vs San Francisco 49ers:All-Time Matchup History

Matchup Overview

The Buffalo Bills and San Francisco 49ers have met 14 times in NFL regular-season and playoff games since 1972. Buffalo Bills hold a dominant all-time edge, leading the series 8–6. Buffalo Bills have had the upper hand recently, going 3–2 in their last 5 meetings. Their most recent matchup ended 35–10 in favor of Buffalo Bills on December 1, 2024.

Next Meeting

No upcoming game scheduled between these teams this season.

All-Time Head-to-Head

Showing 14 games from available historical data. Preseason games are not included.

Date	Season	Away	Score	Home
Dec 1, 24	2024 W13	SF	10–35	BUF
Dec 7, 20	2020	BUF	34–24	SF
Oct 16, 16	2016	SF	16–45	BUF
Oct 7, 12	2012	BUF	3–45	SF
Nov 29, 08	2008	SF	10–3	BUF
Dec 25, 04	2004	BUF	41–7	SF
Dec 1, 01	2001	BUF	0–35	SF
Oct 3, 98	1998	SF	21–26	BUF
Dec 2, 95	1995	BUF	17–27	SF
Sep 12, 92	1992	BUF	34–31	SF
Dec 16, 89	1989	BUF	10–21	SF
Dec 10, 83	1983	SF	23–10	BUF
Dec 20, 80	1980	BUF	18–13	SF
Sep 23, 72	1972	SF	20–27	BUF

Games before the 2010 season: Data from FiveThirtyEight, used under the MIT License and limited to today's franchises.