Carolina Panthers vs San Francisco 49ers:All-Time Matchup History

Matchup Overview

The Carolina Panthers and San Francisco 49ers have met 23 times in NFL regular-season and playoff games since 1995. Carolina Panthers hold a dominant all-time edge, leading the series 13–10. San Francisco 49ers have had the upper hand recently, going 3–2 in their last 5 meetings. Their most recent matchup ended 20–9 in favor of San Francisco 49ers on November 24, 2025.

Next Meeting

No upcoming game scheduled between these teams this season.

All-Time Head-to-Head

Showing 23 games from available historical data. Preseason games are not included.

Date	Season	Away	Score	Home
Nov 24, 25	2025 W12	CAR	9–20	SF
Oct 9, 22	2022 W5	SF	37–15	CAR
Oct 27, 19	2019	CAR	13–51	SF
Sep 10, 17	2017	CAR	23–3	SF
Sep 18, 16	2016	SF	27–46	CAR
Nov 10, 13	2013	CAR	10–9	SF
Oct 24, 10	2010	SF	20–23	CAR
Dec 1, 07	2007	SF	14–31	CAR
Nov 13, 04	2004	CAR	37–27	SF
Nov 17, 01	2001	SF	25–22	CAR
Oct 6, 01	2001	CAR	14–24	SF
Oct 21, 00	2000	SF	16–34	CAR
Sep 9, 00	2000	CAR	38–22	SF
Dec 17, 99	1999	SF	24–41	CAR
Oct 16, 99	1999	CAR	31–29	SF
Dec 5, 98	1998	SF	31–28	CAR
Nov 7, 98	1998	CAR	23–25	SF
Nov 15, 97	1997	CAR	19–27	SF
Sep 28, 97	1997	SF	34–21	CAR
Dec 7, 96	1996	CAR	30–24	SF
Sep 21, 96	1996	SF	7–23	CAR
Dec 9, 95	1995	SF	31–10	CAR
Nov 4, 95	1995	CAR	13–7	SF

Games before the 2010 season: Data from FiveThirtyEight, used under the MIT License and limited to today's franchises.