NFL · All-Time Matchup
Indianapolis Colts
VS
San Francisco 49ers
Indianapolis Colts vs San Francisco 49ers:All-Time Matchup History
Matchup Overview
The Indianapolis Colts and San Francisco 49ers have met 6 times in NFL. Indianapolis Colts hold a dominant all-time edge, leading the series 4–2. Indianapolis Colts have been dominant in recent meetings, winning 4 of their last 5. Their most recent matchup ended 48–27 in favor of San Francisco 49ers on December 23, 2025.
Next Meeting
No upcoming game scheduled between these teams this season.
All-Time Head-to-Head
Showing 6 games from available historical data.
| Date | Away | Score | Home |
|---|---|---|---|
| Dec 23, 25 | SF | 48–27 | IND |
| Oct 25, 21 | IND | 30–18 | SF |
| Aug 25, 18 | SF | 17–23 | IND |
| Oct 8, 17 | SF | 23–26 | IND |
| Sep 22, 13 | IND | 27–7 | SF |
| Aug 15, 10 | SF | 37–17 | IND |
Overall Record
since 2010
Indianapolis Colts
4San Francisco 49ers
26 games in available data
Last 5 Meetings
SF48
@Dec 23
27IND
IND30
@Oct 25
18SF
SF17
@Aug 25
23IND
SF23
@Oct 8
26IND
IND27
@Sep 22
7SF