Indianapolis Colts vs San Francisco 49ers:All-Time Matchup History

Matchup Overview

The Indianapolis Colts and San Francisco 49ers have met 46 times in NFL regular-season and playoff games since 1953. Indianapolis Colts hold a dominant all-time edge, leading the series 27–19. Indianapolis Colts have been dominant in recent meetings, winning 4 of their last 5. Their most recent matchup ended 48–27 in favor of San Francisco 49ers on December 22, 2025.

Next Meeting

No upcoming game scheduled between these teams this season.

All-Time Head-to-Head

Showing 46 games from available historical data. Preseason games are not included.

Date	Season	Away	Score	Home
Dec 22, 25	2025 W16	SF	48–27	IND
Oct 24, 21	2021 W7	IND	30–18	SF
Oct 8, 17	2017	SF	23–26	IND
Sep 22, 13	2013	IND	27–7	SF
Oct 31, 09	2009	SF	14–18	IND
Oct 8, 05	2005	IND	28–3	SF
Nov 24, 01	2001	SF	40–21	IND
Oct 17, 98	1998	IND	31–34	SF
Oct 14, 95	1995	SF	17–18	IND
Sep 9, 89	1989	SF	30–24	IND
Oct 4, 86	1986	IND	14–35	SF
Nov 11, 72	1972	IND	21–24	SF
Nov 15, 69	1969	IND	17–20	SF
Oct 25, 69	1969	SF	24–21	IND
Oct 12, 68	1968	IND	42–14	SF
Sep 14, 68	1968	SF	10–27	IND
Nov 25, 67	1967	IND	26–9	SF
Sep 30, 67	1967	SF	7–41	IND
Dec 17, 66	1966	IND	30–14	SF
Sep 24, 66	1966	SF	14–36	IND
Oct 30, 65	1965	IND	34–28	SF
Oct 2, 65	1965	SF	24–27	IND
Nov 28, 64	1964	IND	14–3	SF
Oct 31, 64	1964	SF	7–37	IND
Oct 12, 63	1963	SF	3–20	IND
Sep 21, 63	1963	IND	20–14	SF
Nov 3, 62	1962	IND	22–3	SF
Oct 6, 62	1962	SF	21–13	IND
Dec 15, 61	1961	IND	27–24	SF
Dec 2, 61	1961	SF	17–20	IND
Dec 17, 60	1960	IND	10–34	SF
Nov 26, 60	1960	SF	30–22	IND
Dec 4, 59	1959	IND	34–14	SF
Nov 21, 59	1959	SF	14–45	IND
Dec 13, 58	1958	IND	12–21	SF
Nov 29, 58	1958	SF	27–35	IND
Dec 7, 57	1957	IND	13–17	SF
Nov 23, 57	1957	SF	21–27	IND
Dec 15, 56	1956	IND	17–30	SF
Dec 1, 56	1956	SF	20–17	IND
Dec 10, 55	1955	IND	24–35	SF
Nov 26, 55	1955	SF	14–26	IND
Dec 10, 54	1954	IND	7–10	SF
Nov 27, 54	1954	SF	13–17	IND
Dec 12, 53	1953	IND	14–45	SF
Nov 28, 53	1953	SF	38–21	IND

Games before the 2010 season: Data from FiveThirtyEight, used under the MIT License and limited to today's franchises.