NFL · All-Time Matchup
Jacksonville Jaguars
VS
San Francisco 49ers
Jacksonville Jaguars vs San Francisco 49ers:All-Time Matchup History
Matchup Overview
The Jacksonville Jaguars and San Francisco 49ers have met 8 times in NFL regular-season and playoff games since 1999. San Francisco 49ers hold a dominant all-time edge, leading the series 5–3. San Francisco 49ers have been dominant in recent meetings, winning 4 of their last 5. Their most recent matchup ended 26–21 in favor of Jacksonville Jaguars on September 28, 2025.
Next Meeting
No upcoming game scheduled between these teams this season.
All-Time Head-to-Head
Showing 8 games from available historical data. Preseason games are not included.
| Date | Away | Score | Home |
|---|---|---|---|
| Sep 28, 25 | JAX | 26–21 | SF |
| Nov 12, 23 | SF | 34–3 | JAX |
| Nov 21, 21 | SF | 30–10 | JAX |
| Dec 24, 17 | JAX | 33–44 | SF |
| Oct 27, 13 | SF | 42–10 | JAX |
| Nov 28, 09 | JAX | 3–20 | SF |
| Dec 17, 05 | SF | 9–10 | JAX |
| Sep 11, 99 | SF | 3–41 | JAX |
Games before the 2010 season: Data from FiveThirtyEight, used under the MIT License and limited to today's franchises.
Overall Record
since 1999
Jacksonville Jaguars
3San Francisco 49ers
58 games in available data
Last 5 Meetings
JAX26
@Sep 28
21SF
SF34
@Nov 12
3JAX
SF30
@Nov 21
10JAX
JAX33
@Dec 24
44SF
SF42
@Oct 27
10JAX